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RESEARCH PRODUCT
Ircinal E, a New Manzamine Derivative from the Indonesian Marine Sponge Acanthostrongylophora ingens
Werner E.g. MüllerRudolf HartmannGeorgios DaletosWeaam EbrahimWeaam EbrahimMousa AltarabeenWenhan LinPeter Prokschsubject
PharmacologyMurine lymphomabiologyStereochemistryAcanthostrongylophora ingensPlant ScienceGeneral MedicineNuclear magnetic resonance spectroscopybiology.organism_classificationMass spectrometrySpongechemistry.chemical_compoundComplementary and alternative medicinechemistryDrug DiscoveryBotanyMoleculeCytotoxicityDerivative (chemistry)description
Chemical investigation of the MeOH extract of the sponge Acanthostrongylophora ingens afforded the new manzamine derivative ircinal E (1), in addition to six known metabolites (2–7). The structure of the new compound was unequivocally elucidated using one- and two-dimensional NMR spectroscopy, as well as high-resolution mass spectrometry. Compounds 1–6 exhibited strong to moderate cytotoxicity against the murine lymphoma L5178Y cell line with IC50 values ranging from 2.8 to 21.7 μM.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-11-01 | Natural Product Communications |