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RESEARCH PRODUCT
Innovations in assisted reproductive technologies: impact on contemporary donor egg practice and future advances.
José BellverMindy S. Christiansonsubject
0301 basic medicineReproductive Techniques Assistedmedicine.medical_treatmentOvarian hyperstimulation syndromeReproductive technologyControlled ovarian hyperstimulationAndrologyEmbryo Culture Techniques03 medical and health sciences0302 clinical medicineInventionsMedicineHumansBlastocystOvarian reserveOvarian Reserve030219 obstetrics & reproductive medicineAssisted reproductive technologyOocyte Donationbusiness.industryObstetrics and GynecologyOocyte cryopreservationmedicine.diseaseOocyte030104 developmental biologymedicine.anatomical_structureReproductive MedicineFemalebusinessForecastingdescription
Innovations in assisted reproductive technologies (ART) have driven progress in the donor egg field since the birth of the first baby derived from a donor egg in 1983. Over time, donor oocytes have become an increasingly used option for patients unable to conceive with autologous oocytes. In donor egg, the unique separation of the oocyte source and recipient uterus has created a model that has propelled advances in ART. Progressive ART innovations that have optimized the oocyte donor and resulting embryo include the following: evaluation of ovarian reserve, controlled ovarian hyperstimulation regimens that reduce the risk of ovarian hyperstimulation syndrome, blastocyst culture, oocyte cryopreservation, and preimplantation genetic testing. For donor egg recipients, methods to optimize the endometrium to maximize implantation include endometrial receptivity testing, immunologic donor-recipient matching, and increased understanding of the uterine microbiome.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-01 | Fertility and sterility |