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RESEARCH PRODUCT
Carotid atherosclerosis and chronic hepatitis C: A prospective study of risk associations
A. MazzolaSalvatore PettaDaniela CabibiAntonio CraxìVito Di MarcoGaspare ParrinelloGiuseppe LicataCalogero CammàAnna LicataSalvatore NovoDaniele TorresGiovanni FazioGiulio Marchesinisubject
Carotid Artery DiseasesMaleLIVER BIOPSYComorbiditySeverity of Illness IndexGastroenterologyBody Mass IndexReference ValuesOdds RatioPrevalenceProspective StudiesProspective cohort studySettore MED/12 - Gastroenterologiamedicine.diagnostic_testBiopsy NeedleSmokingHepatitis CMiddle AgedPrognosisHCV ATHEROSCLEROSI FIBROSISImmunohistochemistryItalyCAROTID ATHEROSCLEROSISFemaleRadiologyAdultmedicine.medical_specialtySettore MED/08 - Anatomia PatologicaCHRONIC HEPATITIS CRisk AssessmentYoung AdultAge DistributionInternal medicineDiabetes mellitusBiopsyHEPATIC FIBROSISConfidence IntervalsmedicineHumansObesitySex DistributionAgedAnalysis of VarianceHepatologybusiness.industryCase-control studyUltrasonography DopplerOdds ratioHepatitis C ChronicHepatologymedicine.diseaseDiabetes Mellitus Type 2Case-Control StudiesMultivariate AnalysisLinear ModelsSteatosisbusinessdescription
BACKGROUND AND AIMS: There are contrasting results in studies of cardiovascular risk in patients with genotype 1 chronic hepatitis C (G1 CHC). We evaluated the prevalence of carotid atherosclerosis compared with a control population in order to assess the potential association between atherosclerosis, host and viral factors, and liver histological features. MATERIALS AND METHODS: One hundred seventy-four consecutive biopsy-proven G1 CHC patients were evaluated by anthropometric and metabolic measurements. One hundred seventy-four patients attending an outpatient cardiology unit were used as controls. Intima-media thickness (IMT) and carotid plaques, defined as focal thickening of > 1.3 mm at the level of common carotid, were evaluated using ultrasonography. All G1 CHC biopsies were scored by one pathologist for staging and grading, and graded for steatosis. RESULTS: Carotid plaques were found in 73 (41.9%) G1 CHC patients compared with 40 (22.9%) control patients (p55 years the prevalence of carotid plaques was similar in those with or without severe fibrosis (25/43, 58.1% versus 22/43, 51.1%; p=0.51). CONCLUSION: Severe hepatic fibrosis is associated with a high risk of early carotid atherosclerosis in G1 CHC patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-06-21 | Hepatology |