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RESEARCH PRODUCT

Comparison of Macular Thickness in Patients with Keratoconus and Control Subjects Using the Cirrus HD-OCT

Rune BrautasetRebecka RosénJan P.g. BergmansonWilliam L. MillerAlejandro CerviñoMikael Nilsson

subject

AdultMaleKeratoconusmedicine.medical_specialtygenetic structuresArticle Subjectlcsh:MedicineKeratoconusAge and sexGeneral Biochemistry Genetics and Molecular BiologySignal strengthOphthalmologyHumansMedicineMacula LuteaIn patientGeneral Immunology and Microbiologybusiness.industrylcsh:RHealthy subjectsGeneral MedicineMiddle AgedControl subjectsmedicine.diseaseeye diseasesCase-Control StudiesOptometryFemaleCirrussense organsbusinessTomography Optical CoherenceResearch Article

description

Purpose.The aim of the present study was to compare macular thickness in patients with keratoconus (KC) with macular thickness in healthy subjects.Subjects and Methods.Twenty-six patients with KC and 52 control subjects were included. The macular structure was evaluated using a Zeiss Cirrus HD-OCT. The scan pattern used was 512 × 128, which covers an area of approximately 6 × 6 mm of the retina. The cube volume was assessed as well as macular thickness in each of the 9 sectors defined by the software.Results.The mean signal strength was significantly lower in the KC group (mean 8.4, range 6–10) compared with the control group (mean 9.7, range 7–10),P<0.0001(unpairedt-test). There were no significant differences in cube volume (unpairedt-test), cube average thickness, or macular thickness between the KC group and the control subjects in any of the retinal locations (one-way ANOVA).Conclusion.Macular structure as measured by OCT in KC subjects should be expected to lie within the range of age and sex matched controls.

yearjournalcountryeditionlanguage
2014-09-08BioMed Research International
https://doi.org/10.1155/2015/832863