6533b834fe1ef96bd129d86f
RESEARCH PRODUCT
Identification and characterization of the nano-sized vesicles released by muscle cells
Yvan CamposValentina Di FeliceDaniele P. RomancinoGaetano PaternitiAngela De LucaAlessandra D'azzoAntonella Bongiovannisubject
Cell typeCellular differentiationBiophysicsBiologyExosomesBiochemistryExosomeExosome; Nanovesicle; Alix; Ozz-E3 ubiquitin ligase; Muscle cellArticleCell Line03 medical and health sciencesMice0302 clinical medicineOzz-E3 ubiquitin ligaseStructural BiologyGeneticsMyocyteAnimalsSecretionMolecular Biology030304 developmental biology0303 health sciencesMuscle CellsSettore BIO/16 - Anatomia UmanaVesicleCalcium-Binding ProteinsCell MembraneMuscle cellCell DifferentiationCell BiologyCell biologyNanostructuresExosomeAlixCell culture030220 oncology & carcinogenesisNanovesicleBiogenesisdescription
AbstractSeveral cell types secrete small membranous vesicles that contain cell-specific collections of proteins, lipids, and genetic material. The function of these vesicles is to allow cell-to-cell signaling and the horizontal transfer of their cargo molecules. Here, we demonstrate that muscle cells secrete nano-sized vesicles and that their release increases during muscle differentiation. Analysis of these nanovesicles allowed us to characterize them as exosome-like particles and to define the potential role of the multifunctional protein Alix in their biogenesis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-20 | FEBS Letters |