(Neo)adjuvant Strategies of Advanced Gastric Carcinoma: Time for a Change?

6533b834fe1ef96bd129e124

RESEARCH PRODUCT

(Neo)adjuvant Strategies of Advanced Gastric Carcinoma: Time for a Change?

Ines Gockel Markus Moehler Theodor Junginger Carl C. Schimanski Peter R. Galle

subject

Oncology medicine.medical_specialty medicine.medical_treatment Gastric carcinoma Stomach Neoplasms Internal medicine medicine Humans Neoplasm Staging Cisplatin Chemotherapy business.industry Carcinoma Gastroenterology Cancer General Medicine medicine.disease Neoadjuvant Therapy digestive system diseases Oxaliplatin Irinotecan Docetaxel Practice Guidelines as Topic business Adjuvant medicine.drug

description

Despite surgical R0 resections, patients with gastric cancer stage UICC II–III have a high risk of recurrence and metachronic metastases. Preliminary evidence exists that adjuvant chemotherapy or neoadjuvant chemo(radio)therapy protocols may improve the prognosis of these patients undergoing surgery of gastric cancer with curative intention. As for palliative regimens, 5-fluorouracil and cisplatin are integral components of such (neo)adjuvant strategies. Upcoming cytostatic agents, i.e. irinotecan, docetaxel, oxaliplatin, and oral fluoropyridines are currently under investigation in new multimodality treatment regimens and may further increase R0 resection rates and may prolong disease-free and overall survival in the treatment of advanced localized gastric cancer.

year	journal	country	edition	language
2005-04-07	Digestive Diseases

https://doi.org/10.1159/000083597

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