6533b835fe1ef96bd129e904
RESEARCH PRODUCT
Granular nuclear inclusion body disease: Fine structure of tibial muscle and sural nerve
Hanns Christian HopfJ. M. SchröderKlaus Günter Krämersubject
Pathologymedicine.medical_specialtymedicine.diagnostic_testPhysiologybusiness.industrySural nerveAnatomyInclusion bodieslaw.inventionCellular and Molecular NeuroscienceCell nucleusmedicine.anatomical_structurePathognomoniclawPhysiology (medical)Hyaline inclusionBiopsyMedicineNeurology (clinical)Electron microscopebusinessHyalinedescription
Fine granular (hyaline) intranuclear inclusion bodies were found in perivascular cells of a muscle and a sural nerve biopsy from a 32-year-old woman with slowly progressive motor disturbances. The hyaline nuclear inclusion bodies could be distinguished from other intranuclear hyaline inclusions by their granularity, the size of the granules (approximately 5-15 nm), and the positive iron staining reaction. They were not seen in muscle fibers or Schwann cells. Because of these apparently pathognomonic structural features the patient appears to present a condition that has not been described before.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-01-01 | Muscle & Nerve |