6533b835fe1ef96bd129ea9b
RESEARCH PRODUCT
Mechanics and self-organization in tissue development
Pedro Gómez-gálvezLuis M. EscuderoJavier BucetaSamira Anbarisubject
Self-organizationPhysicsSelf-organizationTraveling wavesDynamical systems theoryCell packingSortingCompartmentalization (information security)Cell BiologyMechanicsDevelopmental mechanismsLiving systemsCell sortingERKPhenomenonDevelopmental mechanicsSpecialization (functional)MorphogenesisHumansEpitheliaTopology (chemistry)Developmental BiologySignal Transductiondescription
Self-organization is an all-important feature of living systems that provides the means to achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review this concept by addressing the packing organization of cells, the sorting/compartmentalization phenomenon of cell populations, and the propagation of organizing cues at the tissue level through traveling waves. We elaborate on how different theoretical models and tools from Topology, Physics, and Dynamical Systems have improved the understanding of self-organization by shedding light on the role played by mechanics as a driver of morphogenesis. Altogether, by providing a historical perspective, we show how ideas and hypotheses in the field have been revisited, developed, and/or rejected and what are the open questions that need to be tackled by future research.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 |