Emergence of tularemia in France: paradigm of the Burgundy region

6533b835fe1ef96bd129f50a

RESEARCH PRODUCT

Emergence of tularemia in France: paradigm of the Burgundy region

S. Mahy N. Roch Max Maurin Pascal Chavanet Michel Duong Isabelle Pelloux Lionel Piroth

subject

Male Epidemiology MESH: Lymph Nodes Communicable Diseases Emerging Serology Tularemia 0302 clinical medicine MESH: Early Diagnosis Epidemiology Diagnosis MESH: Communicable Diseases Emerging 030212 general & internal medicine MESH: Doxycycline Francisella tularensis Tularemia 0303 health sciences MESH: Tularemia MESH: Middle Aged biology MESH: Real-Time Polymerase Chain Reaction Incidence (epidemiology)[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]Antibody titer General Medicine respiratory system Middle Aged 3. Good health Anti-Bacterial Agents Infectious Diseases Francisella tularensis DNA Doxycycline Female France Fluoroquinolones Adult DNA Bacterial Microbiology (medical)medicine.medical_specialty Real-Time Polymerase Chain Reaction complex mixtures 03 medical and health sciences MESH: Francisella tularensis MESH: Anti-Bacterial Agents medicine Humans Francisella tularensis MESH: Humans 030306 microbiology MESH: Adult MESH: Fluoroquinolones biology.organism_classification medicine.disease bacterial infections and mycoses Virology MESH: DNA Bacterial MESH: Male MESH: France Early Diagnosis bacteria Lymph Nodes MESH: Female Real-time PCR

description

International audience; We report three consecutive cases of tularemia occurring in Burgundy, France, a region previously considered not endemic for tularemia. The patients presented with varied and unspecific clinical manifestations. The epidemiological circumstances, especially the mode of contamination, were not particularly suggestive of tularemia. Serological diagnosis was delayed in two cases because of the lack of significant antibody titers at the time of admission. In contrast, a diagnosis could readily be obtained in all three cases by detection of Francisella tularensis DNA from clinical samples using PCR-based methods. These cases highlight the increased incidence and geographical spread of tularemia in France, and the usefulness of real-time PCR technology for the early diagnostic confirmation of tularemia.

year	journal	country	edition	language
2011-12-01	International Journal of Infectious Diseases

10.1016/j.ijid.2011.08.007 http://dx.doi.org/10.1016/j.ijid.2011.08.007