6533b835fe1ef96bd129f5cd
RESEARCH PRODUCT
Ethopharmacological studies on the effects of antihormones on rodent agonistic behavior with especial emphasis on progesterone.
Paul F. BrainManuela MartinezVicente M. Simónsubject
Malemedicine.medical_specialtyRodentLightmedicine.drug_classAntiandrogensCognitive NeuroscienceAntiandrogenStyrenesBehavioral Neurosciencechemistry.chemical_compoundMiceInternal medicinebiology.animalmedicineAgonistic behaviourAnimalsInterpersonal RelationsCyproteroneCyproterone AcetateProgesteronebiologyBody WeightEstrogen AntagonistsCyproterone acetateEstrogen AntagonistsAndrogen AntagonistsOrgan SizeRatsTamoxifenNeuropsychology and Physiological PsychologyEndocrinologychemistryCyproteroneFemalePsychologyhormones hormone substitutes and hormone antagonistsAfter treatmentAgonistic Behaviormedicine.drugdescription
The effects of a range of antiandrogens and antiestrogens on conflict behaviors in laboratory rats and mice are reassessed in the light of recent studies applying ethophamacological analyses (recording the full spectrum of behaviors) to such investigations. It is argued that any antihostility properties of the antiandrogen cyproterone acetate are largely a consequence of indirect actions on odor communication, whereas antiestrogens (e.g., tamoxifen and CI 680) seem to have more fundamental motivational effects in addition to communicatory actions. A detailed example of the approach is provided in which progesterone (which can be antiandrogenic) is given to rats paired in different ways. The type of pairing has a very substantial effect on the actions seen after treatment, and the ethopharmacological approach generates a better picture of antihormone effect than traditional psychopharmacological tests.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-12-01 | Neuroscience and biobehavioral reviews |