6533b835fe1ef96bd129f6b0
RESEARCH PRODUCT
Rapidly progressive organising pneumonia associated with cytomegalovirus infection in a patient with psoriasis.
F. GuddoMaria MessinaScichilone NicolaVincenzo Belliasubject
Pulmonary and Respiratory MedicineGanciclovirPathologymedicine.medical_specialtyCyclophosphamidemedicine.medical_treatmentCongenital cytomegalovirus infectionlcsh:MedicineConnective tissueInterstitial disease connective diseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioPsoriasismedicineHumansPsoriasiscytomegalovirus infectionInterstitial pneumoniaMechanical ventilationRespiratory distressbusiness.industrylcsh:RMiddle Agedmedicine.diseaseRegimenmedicine.anatomical_structureCryptogenic Organizing PneumoniaCytomegalovirus InfectionsFemaleCardiology and Cardiovascular Medicinebusinessmedicine.drugdescription
A 63-year-old woman experienced progressive respiratory distress and psoriatic plaques. The radiographic images showed diffuse interstitial infiltrates. The surgical open lung biopsy revealed an obliteration of the alveolar spaces by plugs of connective tissue distributed within the terminal bronchioles, alveolar ducts and spaces. No relevant cause was determined, and she was diagnosed with idiopathic organising pneumonia. The patient was discharged with oral glucocorticosteroid and supplemental oxygen therapy. One month later, the patient’s pulmonary status had progressively worsened, and she was re-admitted. She required higher oxygen concentrations and mechanical ventilation. Pharmacological therapy included high-dose steroids and cyclophosphamide. Serological assays revealed high antibodies titers (both IgM and IgG) to cytomegalovirus. Therefore, ganciclovir was added to the regimen. Despite the therapy, she died as a result of the disease. The review of the current literature on the topic is also presented.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-02-03 | Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace |