6533b835fe1ef96bd129fd76

RESEARCH PRODUCT

Synthesis and characterization of novel bile-acid – heteroaryl conjugates with N-(2-aminoethyl)amido linker

Juha KoivukorpiManu LahtinenErkki KolehmainenArto Valkonen

subject

Molecular massBile acidChemistryStereochemistrymedicine.drug_classOrganic ChemistryCrystal structureMass spectrometryAnalytical ChemistryInorganic ChemistryNMR spectra databasemedicineOrthorhombic crystal systemLinkerSpectroscopyConjugate

description

Abstract Four novel bile acid conjugates N-[2-([2,2′]-bithiophen-5-ylmethyl)aminoethyl]-3α-hydroxy-5β-cholan-24-amide (1), N-[2-([2,2′]-bithiophen-5-ylmethyl)aminoethyl]-3α,7α,12α-trihydroxy-5β-cholan-24-amide (2), N-[2-(1H-pyrrol-2-ylmethyl)aminoethyl]-3α-hydroxy-5β-cholan-24-amide (3), N-[2-(pyridin-2-ylmethyl)aminoethyl]-3α-hydroxy-5β-cholan-24-amide (4) have been synthesized in moderate to good yields, and their structures have been characterized by 1H, 13C, 13C DEPT-135, PFG 1H,13C HMQC, and PFG 1H,13C HMBC NMR spectra. Their molecular weights and elemental compositions have been determined by ESI-TOF mass spectrometry and elemental analyses. Crystal structure of 1 characterized with orthorhombic P212121 space group has also been determined.

yearjournalcountryeditionlanguage
2008-12-01Journal of Molecular Structure
https://doi.org/10.1016/j.molstruc.2008.04.057