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RESEARCH PRODUCT
Associations between neuropsychological performance and appetite-regulating hormones in anorexia nervosa and healthy controls: Ghrelin's putative role as a mediator of decision-making.
Fernando Fernández-arandaCristina BotellaZaida AgüeraRafael De La TorreAmaia RodríguezLourdes Garrido-sánchezNadine RiescoJosé Manuel Fernández-realAna B CrujeirasSusana Jiménez-murciaJosé M. MenchónGeorgios PaslakisJosé Carlos Fernández-garcíaFrancisco J. TinahonesMontserrat FitóFelipe F. CasanuevaFrancisco J. OrtegaLuis Serra-majemRoser GraneroRosa M. BañosIsabel SánchezGema Frühbecksubject
0301 basic medicineAdultmedicine.medical_specialtyAnorexia Nervosamedia_common.quotation_subjectDecision MakingAppetite030209 endocrinology & metabolismNeuropsychological TestsBiochemistryModels BiologicalCohort Studies03 medical and health sciencesYoung Adult0302 clinical medicineEndocrinologyWisconsin Card Sorting TestInternal medicineAppetite regulationmedicineHumansNeuropsychological assessmentMolecular Biologymedia_commonmedicine.diagnostic_testbusiness.industryLeptindigestive oral and skin physiologyAppetiteAnorexia nervosaIowa gambling taskNeuropsychological performanceGhrelin030104 developmental biologyEndocrinologyAnorexia nervosa (differential diagnoses)Case-Control StudiesGhrelinbusinesshormones hormone substitutes and hormone antagonistsStroop effectDecision-makingdescription
Anorexia nervosa (AN) is a severe eating disorder accompanied by alterations in endocrinological circuits and deficits in neuropsychological performance. In this study, a series of appetite-regulating hormones (ghrelin, leptin, cholecystokinin, PYY, adiponectin, and visfatin) were measured under fasting conditions in female patients with AN and female healthy controls. All of the participants also underwent a battery of neuropsychological assessment [namely the Iowa Gambling Task (IGT), the Wisconsin Card Sorting Test (WCST), and the Stroop Color and Word Test (SCWT)]. As the main finding, we found that higher ghrelin levels predict better performance in the IGT. Ghrelin may be a putative mediator of decision-making, a finding that has not been described so far. The role of ghrelin in decision-making can only be described as speculative, as there are hardly any additional evidence-based data published up to date. Further studies are warranted.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-02-28 |