6533b835fe1ef96bd12a00cf
RESEARCH PRODUCT
Neuron regeneration reverses 3-acetylpyridine-induced cell loss in the cerebral cortex of adult lizards
Soledad AlcántaraCarlos Lopez-garciaJosé Manuel García-verdugoEnrique Fontsubject
MaleTime FactorsPyridinesMedial cortexCentral nervous systemHippocampusBiologyCell MovementmedicineAnimalsNeurotoxinMolecular BiologyMitosisCerebral CortexNeuronsCell DeathStaining and LabelingGeneral NeuroscienceNeurogenesisLizardsNerve Regenerationmedicine.anatomical_structurenervous systemCerebral cortexNerve DegenerationFemaleNeurology (clinical)NeuronNeuroscienceCell DivisionDevelopmental Biologydescription
Systemic administration of the neurotoxin 3-acetylpyridine to adult lizards results in extensive loss of neurons in the medial cerebral cortex, other brain areas remaining largely unaffected. After the neurotoxic trauma, new cells are produced by mitotic division of cells in the ventricular wall. The new cells migrate along radial glial fibers and replace lost neurons in the medial cortex. Electron microscopic examination of cells labeled with [3H]thymidine confirms that the newly generated cells are neurons. Thus, neuron regeneration can occur in the cerebral cortex of adult lizards.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-06-14 | Brain Research |