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RESEARCH PRODUCT
The effects of sex hormones, prolactin, and chorionic gonadotropin on pineal electrical activity in guinea pigs.
P. SemmL. VollrathC. Demainesubject
Maleendocrine systemmedicine.medical_specialtymedicine.drug_classEstroneGuinea PigsEstroneBiologyInhibitory postsynaptic potentialChorionic GonadotropinPineal GlandCellular and Molecular Neurosciencechemistry.chemical_compoundPineal glandSex FactorsInternal medicinemedicineAnimalsTestosteroneCircadian rhythmTestosteroneProgesteroneCell BiologyGeneral MedicineProlactinProlactinEndocrinologymedicine.anatomical_structurechemistryFemaleGonadotropinhormones hormone substitutes and hormone antagonistsHormonedescription
Microelectrophoretic application of sex hormones onto pineal cells in guinea pigs has shown different responses in pregnant females as compared to males. In pregnant females estrone caused excitation in 74% of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of the cells tested, while progesterone and testosterone, prolactin, and HCG were inhibitory in a majority of the cells. In contrast, in males estrone caused excitation of only 19% but inhibition of 37%. A smaller percentage of cells was inhibited by progesterone, while the predominant response to testosterone was excitation. These results suggest that the pineal gland may be under a feedback control.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1981-09-01 | Cellular and molecular neurobiology |