6533b836fe1ef96bd12a138c

RESEARCH PRODUCT

New amide and dioxopiperazine derivatives from leaves of Breynia nivosa

Werner E. G. M�llerRainer KalscheuerFestus B. C. OkoyeRudolf HartmannBo UmeokoliHao WangZhen LiuFa OnyegbulePeter Proksch

subject

LymphomaStereochemistryMicrobial Sensitivity Tests01 natural sciencesMycobacterium tuberculosisMagnoliopsidaMicechemistry.chemical_compoundAnti-Infective AgentsCell Line TumorAmideDrug DiscoveryBenzene DerivativesAnimalsBreyniaCytotoxicityIC50PharmacologyMolecular Structurebiology010405 organic chemistryChemistryMouse LymphomaTryptophanGeneral Medicinebiology.organism_classificationAntimicrobialAmides0104 chemical sciencesPlant Leaves010404 medicinal & biomolecular chemistryTwo-dimensional nuclear magnetic resonance spectroscopy

description

The first chemical investigation of leaves of Breynia nivosa from Nigeria resulted in the isolation of two new amide derivatives breynivosamides A and B (1 and 2) and two new dioxopiperazine derivatives breynivosines A and B (4 and 5) together with seven known compounds (3, 6-11). The structures of the new compounds were elucidated by 1D, 2D NMR and HRESIMS data as well as by comparison with the literature. All isolated compounds were tested for the cytotoxic and antimicrobial activities. Only cristatin A (6) showed cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 13.9μM while breynivosamide A (1) exhibited moderate antimicrobial activity against Mycobacterium tuberculosis with an MIC value of 25μM.

yearjournalcountryeditionlanguage
2017-05-02Fitoterapia
https://doi.org/10.1016/j.fitote.2017.08.009