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RESEARCH PRODUCT

Heterogeneity of Stem Cells in the Thyroid

Giovanni ZitoGiuseppe PizzolantiCarla GiordanoAntonina Coppola

subject

Parafollicular cellThyroid regenerationendocrine systemendocrine system diseasesCellular differentiationThyroid GlandOct4BiologySettore MED/13 - EndocrinologiaSca103 medical and health sciencesMice0302 clinical medicineThyroid resident stem cellIn vivoEmbryonic stem cells (ES cells)Embryonic Stem CellSolid cell nest (SCN)medicineActivin-A030212 general & internal medicineProgenitor cellTSHAnimalRegeneration (biology)ResearchThyroidThyroid follicleThyrosphereCell DifferentiationEmbryonic stem cellIn vitroOrgan repairCell biologymedicine.anatomical_structureStem cellSide population (SP)Thyroperoxidase (TPO)Thyroglobulin (Tg)Human

description

Identification of thyroid stem cells in the past few years has made important contributions to our understanding of the cellular and molecular mechanisms that induce tissue regeneration and repair. Embryonic stem (ES) cells and induced-pluripotent stem cells have been used to establish reliable protocols to obtain mature thyrocytes and functional follicles for the treatment of thyroid diseases in mice. In addition, the discovery of resident thyroid progenitor cells, along with other sources of stem cells, has defined in detail the mechanisms responsible for tissue repair upon moderate or severe organ injury.In this chapter, we highlight in detail the current state of research on thyroid stem cells by focusing on (1) the description of the first experiments performed to obtain thyroid follicles from embryonic stem cells, (2) the identification of resident stem cells in the thyroid gland, and (3) the definition of the current translational in vivo and in vitro models used for thyroid tissue repair and regeneration.

yearjournalcountryeditionlanguage
2019-01-01
10.1007/978-3-030-24108-7_5http://hdl.handle.net/10447/389589