6533b836fe1ef96bd12a1502
RESEARCH PRODUCT
Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging
Amélie GodardBenoit BusserBenoit BusserEwen BodioXavier Le GuévelJean-luc CollLucie SanceyK. David WegnerYoann RousselinChristine GozeGhadir KalotJacques PliquettUte Resch-gengerFranck Denatsubject
Fluorophore[SDV]Life Sciences [q-bio]Biomedical EngineeringPharmaceutical ScienceBioengineering02 engineering and technology01 natural scienceschemistry.chemical_compoundIn vivoneoplasmsPharmacology[SDV.IB] Life Sciences [q-bio]/BioengineeringHigh contrast010405 organic chemistryOrganic Chemistrytechnology industry and agriculture021001 nanoscience & nanotechnologyBiocompatible materialequipment and suppliesFluorescenceIn vitro3. Good health0104 chemical sciences[SDV] Life Sciences [q-bio]Water solublesurgical procedures operativechemistryBiophysics[SDV.IB]Life Sciences [q-bio]/Bioengineering0210 nano-technologyPreclinical imagingBiotechnologydescription
International audience; A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo. In vitro, the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-04-15 |