6533b836fe1ef96bd12a1bd4
RESEARCH PRODUCT
Chemical constituents from leaves and root bark of Trichilia monadelpha (Meliaceae)
Augustin Ephrem NkengfackNole TsabangSergi Herve AkoneLiu ZhenPierre MkoungaKemda Pamela NangmoKemda Pamela NangmoPeter ProkschKirt MaratTontsa Armelle TsamoTontsa Armelle TsamoWerner E.g. Müllersubject
Meliaceaebiology010405 organic chemistryStereochemistryPlant ScienceSesquiterpenebiology.organism_classificationLimonoidTrichilia monadelpha01 natural sciencesBiochemistryChloride0104 chemical sciences010404 medicinal & biomolecular chemistrychemistry.chemical_compoundchemistryvisual_artmedicinevisual_art.visual_art_mediumBarkMethyleneAgronomy and Crop ScienceTwo-dimensional nuclear magnetic resonance spectroscopyBiotechnologymedicine.drugdescription
Abstract Two new limonoid derivatives designated, monadelphin A (1) and monadelphin B (2) and two new sesquiterpene derivatives named trichins A (3) and B (4) were isolated together with six known compounds (5–10) from the mixture of methylene chloride/methanol (1:1) extract of leaves and root bark of Trichilia monadelpha (Meliaceae) collected in Cameroon. The structures of the new compounds were unambiguously established by detailed spectroscopic analysis including 1D and 2D NMR data in conjunction with high resolution mass spectrometry data and by comparison of these data with those of related compounds described in the literature. Compounds 1–4 were screened for their cytotoxic potential. Compound 1 showed strong cytotoxicity against the mouse lymphoma L5178Y cell line with an IC50 value of 0.62 μg/mL. The biogenetic origin of trichin B (4) from trichin A (3) was also postulated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-02-01 | Phytochemistry Letters |