ChemInform Abstract: Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides.

6533b837fe1ef96bd12a1cfc

RESEARCH PRODUCT

ChemInform Abstract: Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides.

subject

Primary (chemistry)Deprotonation Chemistry Intramolecular force Halide chemistry.chemical_element General Medicine Medicinal chemistry Copper

description

The α-alkylation of deprotonated Strecker products derived from primary amines and aromatic aldehydes with 2-halobenzyl halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to high yields (up to 94% over two steps) by microwave-assisted copper- or palladium-catalyzed intramolecular cross-coupling.

year	journal	country	edition	language
2016-06-01	ChemInform

https://doi.org/10.1002/chin.201629146

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