0000000000851013

AUTHOR

Anne-katrin Bachon

showing 2 related works from this author

ChemInform Abstract: Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides.

2016

The α-alkylation of deprotonated Strecker products derived from primary amines and aromatic aldehydes with 2-halobenzyl halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to high yields (up to 94% over two steps) by microwave-assisted copper- or palladium-catalyzed intramolecular cross-coupling.

Primary (chemistry)DeprotonationChemistryIntramolecular forceHalidechemistry.chemical_elementGeneral MedicineMedicinal chemistryCopperChemInform
researchProduct

Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides

2016

The α-alkylation of deprotonated Strecker products derived from primary amines and aromatic aldehydes with 2-halobenzyl halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to high yields (up to 94% over two steps) by microwave-assisted copper- or palladium-catalyzed intramolecular cross-coupling.

DeprotonationPrimary (chemistry)010405 organic chemistryChemistryIntramolecular forceOrganic ChemistryHalidechemistry.chemical_element010402 general chemistry01 natural sciencesMedicinal chemistryCopper0104 chemical sciencesThe Journal of Organic Chemistry
researchProduct