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RESEARCH PRODUCT
Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides
Anne-katrin BachonTill Opatzsubject
DeprotonationPrimary (chemistry)010405 organic chemistryChemistryIntramolecular forceOrganic ChemistryHalidechemistry.chemical_element010402 general chemistry01 natural sciencesMedicinal chemistryCopper0104 chemical sciencesdescription
The α-alkylation of deprotonated Strecker products derived from primary amines and aromatic aldehydes with 2-halobenzyl halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to high yields (up to 94% over two steps) by microwave-assisted copper- or palladium-catalyzed intramolecular cross-coupling.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-02-03 | The Journal of Organic Chemistry |