6533b837fe1ef96bd12a1d91
RESEARCH PRODUCT
Carnitine congener mildronate protects against stress- and haloperidol-induced impairment in memory and brain protein expression in rats.
Zane DzirkaleVija KlusaSergejs IsajevsJuris RumaksSimons SvirskisUlrika Beitneresubject
Malemedicine.medical_specialtyGlutamate decarboxylaseAmnesiaNerve Tissue ProteinsHippocampal formationGPI-Linked ProteinsNeurotrophic factorsMemoryStress PhysiologicalInternal medicineCarnitinemedicineHaloperidolAvoidance LearningMemory impairmentAnimalsCarnitineRats WistarMaze LearningPharmacologyChemistryGlutamate DecarboxylaseBrain-Derived Neurotrophic FactorBrainRatsEndocrinologyNeuroprotective AgentsSynaptic plasticityAcetylcholinesteraseHaloperidolmedicine.symptomNeuroscienceBiomarkersmedicine.drugMethylhydrazinesdescription
The present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic plasticity, such as brain-derived neurotrophic factor (BDNF), acetylcholine esterase and glutamate decarboxylase 67 (GAD67). Two amnesia models were used: 2h immobilization stress and 3-week haloperidol treatment. Stress caused memory impairment in the passive avoidance test and induced a significant 2-fold BDNF elevation in hippocampal and striatal tissues that was completely inhibited by mildronate. Mildronate decreased the level of GAD67 (but not acetylcholine esterase) expression by stress. Haloperidol decrease by a third hippocampal BDNF and acetylcholine esterase (but not GAD67) expression, which was normalized by mildronate; it also reversed the haloperidol-induced memory impairment in Barnes test. The results suggest the usefulness of mildronate as protector against neuronal disturbances caused by stress or haloperidol.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-05-20 | European journal of pharmacology |