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RESEARCH PRODUCT

Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)

Alain Bertrand DongmoTélesphore Benoît NguelefackMarie-aleth Lacaille-dubois

subject

MaleMimosamedicine.drug_classButanolsAnalgesicDrug Evaluation PreclinicalAdministration OralPainAcacia pennataAcaciaPharmacognosyCarrageenanAnti-inflammatoryMiceAcetic acidchemistry.chemical_compoundFormaldehydeDrug DiscoveryPressuremedicineAnimalsEdemaRats WistarTramadol5-HT receptorAcetic AcidFlavonoidsPharmacologyDose-Response Relationship DrugbiologyTraditional medicinePlant ExtractsAnti-Inflammatory Agents Non-SteroidalAnalgesics Non-Narcoticbiology.organism_classificationStimulation ChemicalHindlimbRatsPlant LeavesDisease Models AnimalNociceptionchemistryFemale

description

The butanolic fraction of dried leaves of Acacia pennata (Mimosaceae) was tested for analgesic and anti-inflammatory activities in animal models. It showed significant protective effects against chemical stimuli (acetic acid and formalin) in the mouse. It also produced a significant increase of the threshold of sensitivity to pressure-induced pain in the rats. The extract revealed an inhibitory effect in carrageenin-induced rat paw oedema in the late phase. The results suggested that a peripheral mechanism is involved in the analgesic, associated to anti-inflammatory effect (NSAIDs-like). Among the class of compounds characterized in this fraction, flavonoids may be mainly responsible for the pharmacological activities.

yearjournalcountryeditionlanguage
2005-04-01Journal of Ethnopharmacology
https://doi.org/10.1016/j.jep.2005.01.030