6533b837fe1ef96bd12a1e70
RESEARCH PRODUCT
Facile access to foldable redox-active flavin-peptide conjugates
Jonas Christopher KölschPol BeseniusSebastian B. BeilSiegfried R. WaldvogelTill OpatzFriedrich StrickerSebastian Preißsubject
chemistry.chemical_classificationOligopeptideChemistryOrganic ChemistryPeptideFlavin groupBiochemistryRedoxCombinatorial chemistryFolding (chemistry)chemistry.chemical_compoundRedox activeheterocyclic compoundsPhysical and Theoretical ChemistryPeptidesDerivative (chemistry)Conjugatedescription
A convenient approach for the synthesis of foldable redox-active flavin peptide conjugates was established. A model β-hairpin oligopeptide motif was utilized to demonstrate that azidolysine side-chains are readily functionalised with an alkyne-bearing flavine derivative. The folding equilibrium of the peptide backbone as well as the redox behaviour of the flavin moieties remains intact after the conjugation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-01 |