6533b837fe1ef96bd12a2001

RESEARCH PRODUCT

Detection of hepatitis B virus markers in sera of asymptomatic hepatitis B surface antigen carriers with special emphasis to pre-S-encoded proteins.

M.p. MannsJ. KnolleWilfred Niels ArnoldGeorg HessMeyer Zum Büschenfelde KhWeber CH. H. DormeyerG. Gerken

subject

MaleHBsAgHepatitis B virusViremiamedicine.disease_causeChronic liver diseaseAsymptomaticGene expressionmedicineHumansProspective StudiesHepatitis B virusHepatitis B Surface Antigensbiologybusiness.industryGastroenterologyHepatitis Bmedicine.diseaseVirologyImmunologyCarrier StateDNA Viralbiology.proteinFemalemedicine.symptomAntibodybusiness

description

Sera of asymptomatic hepatitis B surface antigen (HBsAg) carriers were analyzed for the presence of pre-S-encoded proteins. Four individuals with biopsy-proven chronic hepatitis uniformly expressed pre-S1- and pre-S2-encoded proteins. Individuals who had histologically normal or largely normal livers were heterogeneous with respect to expression of pre-S-encoded proteins. This heterogeneous expression of pre-S-encoded proteins occurred most likely due to difference in serum HBsAg concentration. Alternatively differences in pre-S gene expression need to be considered. Clinically the study indicates that expression of pre-S domains in serum is unrelated to viremia or chronic liver disease.

yearjournalcountryeditionlanguage
1987-01-01Digestion
10.1159/000199577https://pubmed.ncbi.nlm.nih.gov/3440511