6533b837fe1ef96bd12a2788
RESEARCH PRODUCT
Atrial natriuretic peptide secretion during development of the rat supraoptic nucleus
Francesco DieliE. Farina LipariBiagio ValentinoLipari Dsubject
medicine.medical_specialtyendocrine systemHistologyBiophysicsOxytocinSupraoptic nucleusAtrial natriuretic peptidePregnancyInternal medicinesupraopticMedicineAnimalsSecretionRNA MessengerRats Wistarlcsh:QH301-705.5FetusMessenger RNAbusiness.industryReverse Transcriptase Polymerase Chain ReactionnucleushypothalamicCell BiologyImmunohistochemistryRatsEndocrinologyOxytocinAnimals NewbornGene Expression Regulationlcsh:Biology (General)Hypothalamuscardiovascular systemFemalebusinessSupraoptic NucleusAtrial Natriuretic FactorCell Nucleolushormones hormone substitutes and hormone antagonistscirculatory and respiratory physiologymedicine.drugdescription
Since a relationship between atrial natriuretic peptide and oxytocin was recently demonstrated in the heart (Gutkowska et al., 1997), the aim of this study was to determine whether a relationship between the two peptides is present also in the rat hypothalamus. For this purpose, we measured ANP-ontogeny in the rat hypothalamus immunohistochemically and compared it with oxytocin-ontogeny which we previously studied. The results showed that the ANP-peptide and mRNA-ANP start at the 18th day of the fetal life. Our earlier data for oxytocin in the rat hypothalamus showed that only mRNA-oxytocin appeared the 18th day of foetal life (Farina Lipari et al., 2001); thus, at the 18th day of foetal life, mRNA-ANP, ANP-peptide and mRNA-oxytocin are present. We conclude that in the hypothalamus, differently from that in the heart, ANP might play a role on the synthesis of the oxytocin since ANP and its mRNA appear earlier than oxytocin.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-06-01 | European Journal of Histochemistry |