6533b837fe1ef96bd12a27d9

RESEARCH PRODUCT

Catalytic activity of a CuGHK peptide-based porous material

Carlos Marti-gastaldoNuria MartínNeyvis Almora-barriosFrancisco G. Cirujano

subject

Benzaldehydechemistry.chemical_classificationchemistry.chemical_compoundNitroaldol reactionchemistryNitromethaneLysineSide chainMoleculePeptideCombinatorial chemistryCatalysisCatalysis

description

The CuGHK peptide-based porous material with a periodic distribution of pockets decorated with lysine side chain active sites was synthesized using a room temperature one-step method and used as a heterogeneous organocatalyst. The pockets are capable of benzaldehyde molecule uptake and show high activity in the Henry reaction with nitromethane. Mechanistic pathways are investigated using an integrative experimental/computational approach.

https://doi.org/10.1039/d1cy00670c