6533b837fe1ef96bd12a297b
RESEARCH PRODUCT
Nitric oxide synthase containing periglomerular cells are GABAergic in the rat olfactory bulb.
María Gutièrrez-mecinasAna Isabel Marqués-maríFrancisco José Martínez-guijarroCarlos CrespoFrancisco Javier Gracia-llanesJosé Miguel Blasco-ibáñezsubject
Olfactory systemmedicine.medical_specialtyOlfactory NervePopulationCentral nervous systemPresynaptic TerminalsOlfactionNitric OxideSynaptic TransmissionOlfactory nerveInternal medicinemedicineAnimalsRats Wistareducationgamma-Aminobutyric AcidNeuronseducation.field_of_studybiologyChemistryGeneral NeuroscienceNeural InhibitionImmunohistochemistryOlfactory BulbCell biologyOlfactory bulbRatsNitric oxide synthaseEndocrinologymedicine.anatomical_structurenervous systemSynapsesbiology.proteinGABAergicNitric Oxide Synthasedescription
In the olfactory glomeruli of the rat olfactory bulb, there is a population of periglomerular cells (PG) that contains the neuronal isoform of the nitric oxide synthase (nNOS). To date, these PG have not been characterized neurochemically and it has not been determined whether they are type 1 (GABAergic PG that receive synaptic contacts from the olfactory axons) or type 2 PG (non-GABAergic PG that do not receive synapses from the olfactory axons). Combining pre-embedding NADPH-diaphorase histochemistry and post-embedding immunoperoxidase detection of GABA, we demonstrate that nNOS-containing PG are GABAergic and therefore, belong to the type 1 PG. The possible actions of nitric oxide in the olfactory glomeruli are discussed.
year | journal | country | edition | language |
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2003-09-03 | Neuroscience letters |