6533b837fe1ef96bd12a302f

RESEARCH PRODUCT

The effect of Keyhole Limpet Hemocyanin (KLH) on the rat bladder

G. PauliniK. F. KlippelG. Hutschenreiter

subject

Cancer ResearchPathologymedicine.medical_specialtyBladder cancerbiologybusiness.industryImmunologyhemic and immune systemschemical and pharmacologic phenomenaurologic and male genital diseasesmedicine.diseasecomplex mixturesOncologyImmunologyAdjuvant therapybiology.proteinImmunology and AllergyMedicinebusinesstherapeuticsRat BladderKeyhole limpet hemocyanin

description

Immunostimulation with agents such as BCG or KLH may represent an adjuvant therapy in treating patients with bladder cancer. To investigate the effects of direct instillation and injection of KLH into the bladder of sensitized and nonsensitized rats, KLH was injected submucosally into the bladder. Histologically, a marked inflammatory reaction was seen without ulcerations.

https://doi.org/10.1007/bf00199328