6533b837fe1ef96bd12a326a
RESEARCH PRODUCT
Papel del médico de familia en el diagnóstico concomitante de mieloma y amiloidosis primaria en una misma paciente. Caso clínico
F. Andrea Rodríguez-lagosJosé V SorlíMichelle C. Calviño-naveiraNuria Estañ Capellsubject
medicine.medical_specialtyPlasma CellsImmunofluorescenceGastroenterologyHypogammaglobulinemia03 medical and health sciences0302 clinical medicineInternal medicineBiopsymedicine030212 general & internal medicineMelanomaDexamethasoneMultiple myelomaHematologymedicine.diagnostic_testbusiness.industryCongo RedAmyloidosisGeneral Medicinemedicine.diseaseThalidomidemedicine.anatomical_structure030228 respiratory systemBone marrowMultiple MyelomabusinessMetges de famíliamedicine.drugdescription
Multiple Myeloma is a myeloproliferative disorder of plasma cells, which may be complicated with secondary amyloidosis. We report a 48 year old woman consulting to primary care for weight loss and malaise. An initial laboratory study revealed a hypogammaglobulinemia with a monoclonal component and lambda light chains. These results motivated her derivation to hematology: her serum calcium was 11.8 mg/dl, immunofluorescence showed a monoclonal component of lambda chains and urine Bence-Jones protein was positive. A bone marrow biopsy confirmed plasma cell infiltration. A Congo-red stain of a rectal biopsy was positive. The patient was treated with thalidomide, bortezomid and dexamethasone.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-11-01 |