6533b837fe1ef96bd12a3326
RESEARCH PRODUCT
Oxidative decarboxylation of naproxen.
Jaime PrimoRamón Martínez-máñezFrancisco BoscaMiguel A. MirandaLirios VañoJuan Sotosubject
NaproxenChemistryDecarboxylationPharmaceutical ScienceElectrochemistryOxidantsMedicinal chemistrychemistry.chemical_compoundNaproxenmedicineElectrochemistrySolventsOrganic chemistryMoietyChemical stabilityCarboxylatePhototoxicityOxidation-ReductionOxidative decarboxylationmedicine.drugdescription
The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8(2-)] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pi-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-05-01 | Journal of pharmaceutical sciences |