Increasing adiposity in normal ovulatory women affects adipocytokine expression in subcutaneous and visceral abdominal fat

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RESEARCH PRODUCT

Increasing adiposity in normal ovulatory women affects adipocytokine expression in subcutaneous and visceral abdominal fat

Enrico Carmina Michelene Chu P.a. Vardhana Drew V. Tortoriello Rogerio A. Lobo Cary Dicken

subject

Adult Ovulation medicine.medical_specialty Settore MED/09 - Medicina Interna Adipokine Adipose tissue Intra-Abdominal Fat Overweight Body Mass Index Settore MED/13 - Endocrinologia Insulin resistance Adipokines ADIPONECTIN OBESITY LEPTIN CARDIOVASCULAR RISK PCOS HYPERANDROGENISM Internal medicine Humans Medicine Adiposity Adiponectin business.industry Leptin nutritional and metabolic diseases Obstetrics and Gynecology General Medicine medicine.disease Settore MED/40 - Ginecologia E Ostetricia Obesity Subcutaneous Fat Abdominal Endocrinology Case-Control Studies Female Insulin Resistance medicine.symptom business Body mass index hormones hormone substitutes and hormone antagonists

description

Abstract Objective To determine which adipocytokines are differentially expressed as a function of body mass index (BMI), to compare expression of adipocytokines in abdominal subcutaneous and omental fat, and to correlate these findings with serum levels, BMI, and parameters of insulin resistance. Methods Serum and subcutaneous (sc) and omental (om) tissue were obtained from lean and obese ovulatory women undergoing gynecologic surgery. We determined adipocytokine expression in sc versus om abdominal fat and related this to increasing BMI. Results Serum leptin was higher and adiponectin lower in overweight subjects. Adipocytokines had higher expression in sc abdominal versus om adipose tissue with the most significant difference observed for leptin (P = 0.01). As BMI increased, sc leptin expression increased and adiponectin expression decreased. The leptin/adiponectin ratio correlated significantly with BMI (R = 0.84, P = 0.0001). Conclusion Increased adipocytokine expression correlates with BMI. Abdominal sc tissue has greater adipocytokine expression overall. The serum leptin/adiponectin ratio is highly correlated with BMI. These data may help in our understanding of how obesity affects women in a variety of ways.

year	journal	country	edition	language
2008-11-22	International Journal of Gynecology & Obstetrics

https://doi.org/10.1016/j.ijgo.2008.10.006