6533b838fe1ef96bd12a3a0e
RESEARCH PRODUCT
Preparation of 7-Alkoxylated Furanopyrones: Semisynthesis of (−)-Etharvensin, a New Styryl-Lactone from Goniothalamus arvensis
Almudena BermejoAnd M. Carmen Zafra-poloM. Amparo BlázquezDiego CortesAngel Serranosubject
Pharmacologychemistry.chemical_classificationStem barkbiologyStereochemistryOrganic ChemistryPharmaceutical Sciencebiology.organism_classificationSemisynthesisAnalytical Chemistrychemistry.chemical_compoundComplementary and alternative medicinechemistryDrug DiscoveryMolecular MedicineDerivative (chemistry)EtharvensinGoniothalamusLactonedescription
A new furanopyrone derivative, (−)-etharvensin (1), was isolated from the stem bark of Goniothalamus arvensis. Semisynthesis of the 7-ethoxyfuranopyrone 1 was achieved by addition of EtOH in concentrated acid medium to the unsaturated α-pyrone (+)-altholactone (2). This protocol constitutes a novel, direct (single-step), and efficient method to prepare this class of bioactive compounds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-12-01 | Journal of Natural Products |