6533b838fe1ef96bd12a3a7b
RESEARCH PRODUCT
Polyaza[n]paracyclophanes as synthetic models of Zn containing enzymes. The role of a non coordinated nitrogen atom in the proximity of the metal
Enrique García-españaConxa SorianoVictor MarcelinoM. Isabel BurgueteSantiago V. LuisJuan F. MiravetBelén Altavasubject
chemistry.chemical_classificationMetalHydrolysisEnzymeNitrogen atomchemistryStereochemistryvisual_artOrganic ChemistryDrug Discoveryvisual_art.visual_art_mediumBiochemistryCatalysisdescription
Abstract 2,6,9,13-Tetraaza[14]paracyclophane ( 3, B323 ) represents a simple model for Zn containing enzymes like HCAII which possess additional reactive groups in the proximity of the metal center. The Zn 2+ . 3 complex shows notable catalytic activity for the hydrolysis of p -nitrophenyl acetate. Structural modifications of 3 which affect to the non coordinated nitrogen atom greatly modify the catalytic activity of the receptor.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-03-01 | Tetrahedron |