6533b838fe1ef96bd12a3aad
RESEARCH PRODUCT
Structure and Synthesis of a New Indole Alkaloid, 19 (S)-Hydroxy-Nb-methylraumacline, Obtained by the Biotransformation of Ajmaline in Plant Cell Cultures of Rauwolfia Serpentina Benth.
Hiromitsu TakayamaShinya SudaJoachim StöckigtNorio AimiShin-ichiro SakaiSusanne EndreβMariko Kitajimasubject
Indole alkaloidbiologyStereochemistryAlkaloidVerbenaceaeOrganic Chemistrybiology.organism_classificationBiochemistryChemical synthesisAjmalinechemistry.chemical_compoundBiotransformationBiosynthesischemistryCell cultureDrug Discoverymedicinemedicine.drugdescription
Abstract From the plant cell suspension cultures of Tauwolfia serpentina Benth ., which were cultivated in the alkaloid-production medium after feeding of ajmaline (1) , a new indole alkaloid 19- ( S )-hydroxy- N b -methylraumacline ( 4 ) was isolated. The structure of 4 first elucidated by spectroscopic analysis was determined by the chemical synthesis from ajmaline ( 1 ).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-03-01 | Tetrahedron |