6533b838fe1ef96bd12a3c1f

RESEARCH PRODUCT

Non-convulsive status epilepticus associated with tiagabine in a pediatric patient

Liberia CusumanoAntonina FontanaSalvatore Mangano

subject

MaleTiagabinemedicine.medical_treatmentNipecotic AcidsStatus epilepticusNon-convulsive status epilepticuElectroencephalographyCentral nervous system diseaseEpilepsyStatus EpilepticusDevelopmental NeuroscienceRefractorymedicineHumansTiagabineEpilepsymedicine.diagnostic_testbusiness.industryElectroencephalographyGeneral Medicinemedicine.diseaseAnticonvulsantnervous systemEl NiñoChild PreschoolAnesthesiaPediatrics Perinatology and Child HealthAnticonvulsantsEpilepsies PartialNeurology (clinical)medicine.symptombusinessmedicine.drug

description

We report a 4-year-old patient who developed non-convulsive status epilepticus (NCSE) following tiagabine (TGB) as add-on treatment for refractory partial seizures. NCSE occurred while the patient received TGB 0.83mg/kg/day. In our case, the TGB reduction led to a significant improvement of electroclinical features. The mechanisms of this abnormal effect are not clear. GABA-ergic hyperfunction and/or multiplicity of interlinked brain GABA systems associated with individual specific sensitivity could play a critical role in the pathogenesis of NCSE. This is the first report of NCSE documented by electroencephalogram (EEG) in a child under 12 years of age on TGB treatment. © 2003 Elsevier Science B.V. All rights reserved.

yearjournalcountryeditionlanguage
2003-09-18Brain and Development
https://doi.org/10.1016/s0387-7604(03)00028-7