6533b838fe1ef96bd12a464b
RESEARCH PRODUCT
A dinucleating ligand which promotes DNA cleavage with one and without a transition metal ion.
Elena SalvadorSacramento FerrerJuan C. Mareque-rivasJavier CalvoEnrique García-españaJavier Hernández-gilsubject
LigandPyridinesMetal ions in aqueous solutionInorganic chemistryMetals and AlloysGeneral ChemistryDNALigandsTransition metal ionsCatalysisSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialschemistry.chemical_compoundchemistryDna cleavageCoordination ComplexesPolymer chemistryMaterials ChemistryCeramics and CompositesTransition ElementsNeutral phDNA CleavageDNAPlasmidsdescription
The dinucleating ligand L (1,3-bis[bis(pyridin-2-ylmethyl)amino]propan-2-ol) combined with metal ions efficiently cleaves DNA when M : L is 1 : 1 (M = Co(II) or Fe(III)) at pH 5.5–7.0, with free L being more active at acidic pH than when bound to Zn(II), Cu(II) or Ni(II) at neutral pH.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-03-29 | Chemical communications (Cambridge, England) |