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RESEARCH PRODUCT
Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease
L Gisbert-ferrándizJesus Cosin-rogerC Bausetsubject
lcsh:MedicineReviewDiseaseGut floraBioinformaticsInflammatory bowel disease03 medical and health sciences0302 clinical medicineMetabolomicsImmune systeminflammatory bowel diseaseBiopsymedicine030304 developmental biology0303 health sciencesGastrointestinal tractbiologymedicine.diagnostic_testbusiness.industrylcsh:RbiomarkersGeneral Medicinebiology.organism_classificationmedicine.diseasemetabolomicsPotential biomarkers030211 gastroenterology & hepatologybusinessdescription
Inflammatory bowel disease (IBD) is a relapsing chronic disorder of the gastrointestinal tract characterized by disruption of epithelial barrier function and excessive immune response to gut microbiota. The lack of biomarkers providing early diagnosis or defining the status of the pathology difficulties an accurate assessment of the disease. Given the different metabolomic profiles observed in IBD patients, metabolomics may reveal prime candidates to be studied, which may help in understanding the pathology and identifying novel therapeutic targets. In this review, we summarize the most current advances describing the promising metabolites such as lipids or amino acids found through untargeted metabolomics from serum, faecal, urine and biopsy samples.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-01 | Journal of Clinical Medicine |