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RESEARCH PRODUCT
"Bull’s eye” appearance of hepatocellular adenomas in patients with glycogen storage disease type I — atypical magnetic resonance imaging findings: Two case reports
Daniele MarinFederica VernuccioStephanie AustinPriya S. KishnaniMathias MeyerCynthia D. Guysubject
Pathologymedicine.medical_specialtyGadoxetate Disodium03 medical and health sciencesMagnetic resonance imaging0302 clinical medicineCase reportmedicineGlycogen storage diseaseIn patientGlycogen storage diseaseGlycogen storage disease type Imedicine.diagnostic_testbusiness.industryMagnetic resonance imagingGeneral MedicineHepatocellular adenomaequipment and suppliesmedicine.diseaseHepatocellular adenomadigestive system diseasesBull’s eye030220 oncology & carcinogenesis030211 gastroenterology & hepatologyGadoxetate disodiumBull's Eyebusinesshuman activitiesdescription
BACKGROUND Hepatocellular adenomas are rare tumors that can occur in patients with glycogen storage disease type I. CASE SUMMARY We herein report two cases of histologically proven hepatocellular adenomas in patients with glycogen storage disease type I. Magnetic resonance imaging (MRI) was performed after bolus injection of gadoxetate disodium, a liver-specific gadolinium-based MRI contrast agent. In the present cases, some of the hepatocellular adenomas showed unexpectedly a “bull’s eye” appearance on T2-weighted and post-contrast images, which was not previously described as imaging findings of hepatocellular adenomas in glycogen storage disease. A bull’s eye appearance on T2-weighted images can be encountered in both benign (i.e., abscess) or malignant (i.e., epithelioid hemangioendothelioma, cholangio-carcinoma, and metastases) hepatic lesions. CONCLUSION We present two cases of hepatocellular adenomas in patients with glycogen storage disease type 1, in which gadoxetate disodium-MRI showed atypical imaging findings for hepatocellular adenomas. At present there is no systematic study evaluating MRI findings of hepatocellular adenomas in patients with glycogen storage disease, further studies are needed to specifically investigate this issue.
year | journal | country | edition | language |
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2021-02-01 | World Journal of Clinical Cases |