6533b838fe1ef96bd12a52e5
RESEARCH PRODUCT
Prenatal cocaine alters later responses to morphine in adult male mice.
Marta Rodríguez-ariasCarmen ManzanedoMaría A. AguilarJosé MiñarroC. MaldonadoJosefina Estellessubject
Malemedicine.medical_specialtyBiogenic AminesOffspringmedicine.medical_treatmentPharmacologyMotor ActivityMiceCocaineRewardPregnancyInternal medicinemedicineAnimalsInterpersonal RelationsSalineBiological PsychiatryPharmacologyBrain ChemistryPregnancyBehavior AnimalMorphinePrenatal cocaine exposuremedicine.diseaseConditioned place preferenceAggressionAnalgesics OpioidMonoamine neurotransmitterEndocrinologyPrenatal Exposure Delayed EffectsToxicityMorphineExploratory BehaviorConditioning OperantFemalePsychologymedicine.drugdescription
Mice prenatally exposed to cocaine (25 mg/kg), physiological saline or non-treated during the last 6 days of pregnancy were evaluated as adults for the rewarding properties of 2 mg/kg of morphine, using the conditioned place preference (CPP) procedure. Likewise, isolated animals underwent a social interaction test with conspecifics after receiving the same morphine dose. Unlike control or animals pre-treated with saline, subjects prenatally treated with cocaine did not develop CPP with this dose of morphine. Only cocaine-exposed animals showed increased threat, avoidance and fleeing during the social encounter. No differences in motor effects of morphine were observed. Analysis of monoamines revealed effects of housing conditions, isolated animals having fewer DOPAC but higher levels of HVA than those grouped, but in both groups there was a decrease in DOPAC in cocaine- and saline-treated mice. Prenatal cocaine exposure decreases the response to the rewarding properties of drugs in mature offspring. They also implicate cocaine consumption during pregnancy could affect the response of offspring to take other drugs of abuse.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-02-07 | Progress in neuro-psychopharmacologybiological psychiatry |