6533b839fe1ef96bd12a59f2

RESEARCH PRODUCT

Magnetofection of acoustically active „magnetic microspheres“ (Magnetobubbles) — Induction of angiogenesis via non-viral transfection of VEGF

Iva NeshkovaBernd GansbacherT. HolzbachR. E. GiuntaMoritz A. KonerdingChristian PlankDialekti VlaskouHans-guenther Machens

subject

integumentary systembiologybusiness.industryChemistryAngiogenesisVEGF receptorsUltrasoundSkin flapequipment and suppliesNon viral transfectioneye diseasesMicrospherebiology.proteinMagnetofectionCancer researchbusinesshuman activitiesPerfusion

description

Adenoviral transduction of the VEGF gene in an oversized skin flap increases flap survival and perfusion. In this study we investigated the potential of magnetofection of magnetic lipospheres containing VEGF165-cDNA on survival and perfusion of ischemic skin flaps and evaluated the method with respect to the significance of applied magnetic field and ultrasound.

yearjournalcountryeditionlanguage
2009-01-01
https://doi.org/10.1007/978-3-642-00625-8_102