6533b839fe1ef96bd12a6726
RESEARCH PRODUCT
Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa
Frédéric JanvierGuillaume MiltgenPatrick PlésiatMaxime BourThomas JovéDamien FournierArmelle PouzolKaty Jeannotsubject
PharmacologyTransposable elementSerotype0303 health sciencesLineage (genetic)030306 microbiologymedicine.drug_classPseudomonas aeruginosaAntibioticseducationBiologymedicine.disease_cause16S ribosomal RNA3. Good healthMicrobiology03 medical and health sciencesInfectious Diseases[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyColistinmedicinePharmacology (medical)Gene030304 developmental biologymedicine.drugdescription
Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor the gene encoding the rare class C β-lactamase PAC-1 on a chromosomally located Tn 1721 -like transposon. The bla PAC-1 gene was associated with the 16S rRNA methylase determinant rmtF2 , which confers pan-aminoglycoside resistance.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-12-01 |