6533b83afe1ef96bd12a719c

RESEARCH PRODUCT

Synergistic activation of AMPK prevents from polyglutamine-inducedtoxicity inCaenorhabditis elegans

S. C. Torres-sánchezJosé Bono-yagüeMaría Dolores SequedoV. Fornés-ferrerJm MillánPascual SanzMaria Adelaida Garcia-gimenoDavid HervásAna Pilar Gómez-escribanoRafael P. Vázquez-manrique

subject

0301 basic medicineAMPKProtein subunitMutantEnzyme ActivatorsAMP-Activated Protein KinasesProtein Serine-Threonine KinasesProtein Aggregation PathologicalpolyQ toxicityArticleAnimals Genetically ModifiedProtein Aggregates03 medical and health sciences0302 clinical medicineRNA interferenceAutophagymedicineAnimalsAMPK Caenorhabditis elegans Metformin Salycilate Synergy polyQ toxicityCaenorhabditis elegans ProteinsCaenorhabditis elegansLoss functionCaenorhabditis elegansNeuronsPharmacologybiologyChemistrySalycilateAutophagyAMPKDrug Synergismbiology.organism_classificationSalicylatesMetforminCell biologyMetforminEnzyme ActivationSynergy030104 developmental biology030220 oncology & carcinogenesisMutationProteostasisPeptidesmedicine.drug

description

11 páginas, 4 figuras. Supplementary material related to this article can be found, in the online version, at doi: https://doi.org/10.1016/j.phrs.2020.105105.

yearjournalcountryeditionlanguage
2020-01-01
10.1016/j.phrs.2020.105105http://hdl.handle.net/10261/219295