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RESEARCH PRODUCT
Myelin Basic Protein synthesis is regulated by small non‐coding RNA 715
Robin WhitePaul Van Der ValkMaarten E. WitteJack Van HorssenChristina MoosHeiko J. LuhmannNina M. BauerBenjamin Altenheinsubject
Multiple SclerosisCytoplasmic GranulesBiochemistryCell LineMiceGeneticsmedicineProtein biosynthesisAnimalsHumansMRNA transportRNA MessengerMolecular BiologyMyelin SheathMessenger RNAbiologyScientific ReportsOligodendrocyte differentiationBrainRNAMyelin Basic ProteinNon-coding RNAMolecular biologyOligodendrocyteRatsMyelin basic proteinOligodendrogliamedicine.anatomical_structureGene Expression RegulationProtein Biosynthesisbiology.proteinRNA Small Untranslateddescription
Oligodendroglial Myelin Basic Protein (MBP) synthesis is essential for myelin formation in the central nervous system. During oligodendrocyte differentiation, MBP mRNA is kept in a translationally silenced state while intracellularly transported, until neuron-derived signals initiate localized MBP translation. Here we identify the small non-coding RNA 715 (sncRNA715) as an inhibitor of MBP translation. SncRNA715 localizes to cytoplasmic granular structures and associates with MBP mRNA transport granule components. We also detect increased levels of sncRNA715 in demyelinated chronic human multiple sclerosis lesions, which contain MBP mRNA but lack MBP protein.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-01 | EMBO reports |