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RESEARCH PRODUCT
Adipokines and Lipoproteins: Modulation by Antihyperglycemic and Hypolipidemic Agents
Dragana NikolicAli A. RizviGiuseppe MontaltoNicola AbateRizzo ManfrediManfredi RizzoHanaa S. SallamHanaa S. Sallamsubject
medicine.medical_specialtyLipoproteinsEndocrinology Diabetes and Metabolismmedicine.medical_treatmentAdipokineAdipose tissueIncretinsNiacinAnti-Obesity AgentsInsulin resistanceAdipokinesInternal medicineInternal MedicineAnimalsHumansHypoglycemic AgentsInsulinMedicineHypolipidemic AgentsMetabolic Syndromebusiness.industryInsulinFibric AcidsEzetimibemedicine.diseaseLipidsMetforminGlucoseEndocrinologyAdipose TissueHypolipidemic AgentsAzetidinesThiazolidinedionesAnti-Obesity AgentsHydroxymethylglutaryl-CoA Reductase InhibitorsInsulin ResistanceMetabolic syndromebusinessHormonedescription
Abstract Adipose tissue is an endocrine organ that secretes a number of hormones and metabolically active substances that impact energy metabolism and insulin sensitivity. These inflammatory markers are collectively referred to as adipocytokines, or adipokines. Adipose tissue's functional capacity and metabolic activity vary among individuals, thus partly explaining the incomplete overlap between obesity and the metabolic syndrome. The functional failure of adipose tissues results in changed energy delivery and impaired glucose consumption, triggering self-regulatory mechanisms to maintain homeostasis. Antihyperglycemic, hypolipidemic, antiobesity, and angiotensin II receptor blocker drugs influence adipokine levels in different ways. However, clinical data are still scarce and the clinical relevance of these effects needs to be fully determined.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-02-01 | Metabolic Syndrome and Related Disorders |