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RESEARCH PRODUCT

Incomplete Gestation has an Impact on Cognitive Abilities in Autism Spectrum Disorder

Sylvie RouxElie SalibaGabriele TripiFrédérique Bonnet-brilhaultMaëva BrayetteJoëlle MalvyRomuald BlancLaura Ponson

subject

MaleAdolescentCognitive abilitiebehavioral disciplines and activities03 medical and health sciencesNonverbal communicationCognition0302 clinical medicinePregnancyModerately and late pretermmental disordersDevelopmental and Educational PsychologymedicineCognitive developmentHumans0501 psychology and cognitive sciencesAutism spectrum disorderRisk factorChildFull Term05 social sciencesInfant NewbornRetrospective cohort studyCognitionmedicine.diseaseAutism spectrum disorderChild PreschoolPremature BirthAutismFemaleCognition DisordersPsychologyEarly termInfant Premature030217 neurology & neurosurgery050104 developmental & child psychologyClinical psychology

description

Extreme prematurity is known as a risk factor for autism spectrum disorder (ASD). However, the association between prematurity and ASD, for children born moderately and late preterm (MLPT) and those born early term (ET), is less established. This retrospective study aimed to characterize the phenotypic characteristics (i.e. behavioral profile and cognitive abilities) of 254 children with ASD, between 3 and 15 years of age, born MLPT (19 children), ET (60 children) and full term (175 children). MLPT and ET births do not modify ASD symptomatology, but modify cognitive development. The results highlight that incomplete gestation, i.e., MLPT or ET, has a negative impact on both verbal and nonverbal cognitive abilities, in children with neurodevelopmental vulnerability.

yearjournalcountryeditionlanguage
2019-07-02Journal of Autism and Developmental Disorders
https://doi.org/10.1007/s10803-019-04105-x