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RESEARCH PRODUCT
Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons from Cultured Cells to Animal Models
Rizzo ManfrediAndrea ArmaniStefania GoriniElisabetta CamajaniElisabetta CamajaniMassimiliano CaprioAlessandra Feracosubject
QH301-705.5glucose metabolismAdipose tissueReviewType 2 diabetesCarbohydrate metabolismMuscle DevelopmentBioinformaticsCatalysisInorganic ChemistryInsulin resistanceMyokineAnimalsHumansMedicinePhysical and Theoretical ChemistryBiology (General)Muscle SkeletalMolecular BiologyQD1-999Spectroscopybusiness.industryOrganic ChemistrySkeletal musclefree fatty acidsGeneral Medicinemedicine.diseaseComputer Science Applicationsadipose tissueglycemiaDisease Models AnimalChemistrymedicine.anatomical_structureDiabetes Mellitus Type 2Adipose tissue Free fatty acids Glucose metabolism Glycemia Myofibers Animals Diabetes Mellitus Type 2 Humans Muscle Skeletal Disease Models Animal Insulin Resistance Muscle DevelopmentInsulin ResistancebusinessThermogenesismyofibersHomeostasisdescription
Skeletal muscle is essential to maintain vital functions such as movement, breathing, and thermogenesis, and it is now recognized as an endocrine organ. Muscles release factors named myokines, which can regulate several physiological processes. Moreover, skeletal muscle is particularly important in maintaining body homeostasis, since it is responsible for more than 75% of all insulin-mediated glucose disposal. Alterations of skeletal muscle differentiation and function, with subsequent dysfunctional expression and secretion of myokines, play a key role in the pathogenesis of obesity, type 2 diabetes, and other metabolic diseases, finally leading to cardiometabolic complications. Hence, a deeper understanding of the molecular mechanisms regulating skeletal muscle function related to energy metabolism is critical for novel strategies to treat and prevent insulin resistance and its cardiometabolic complications. This review will be focused on both cellular and animal models currently available for exploring skeletal muscle metabolism and endocrine function.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-08-01 | International Journal of Molecular Sciences |