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RESEARCH PRODUCT
The Prevalence of Chronic Cerebrospinal Venous Insufficiency in Meniere Disease: 24-Month Follow-up after Angioplasty
Pier Paolo CavazzutiMarco De VincentisVincenzo GiuglianoLuigi CalifanoAldo BrunoRoberto FilipoFrancesca SalafiaMarisanta NapolitanoDiego MastrangeloLaura CagnoniAntonio GrecoSalvatore MazzoneGiuseppe AttanasioMarika ViccaroBenedetto BernardoEleonora Mascisubject
AdultMalemedicine.medical_specialtyPercutaneousTime Factorsmedicine.medical_treatmentVenographyAsymptomaticMagnetic resonance angiography03 medical and health sciences0302 clinical medicineRisk FactorsAngioplastymedicinePrevalenceHumansRadiology Nuclear Medicine and imaging030223 otorhinolaryngologyInternal jugular veinMeniere DiseaseAgedUltrasonography Doppler Duplexmedicine.diagnostic_testbusiness.industryPhlebographyMiddle Agedmedicine.diseaseSurgeryChronic cerebrospinal venous insufficiencyCerebrovascular DisordersTreatment OutcomeItalySpinal CordVenous InsufficiencyAzygos VeinCase-Control StudiesChronic DiseaseFemaleMeniere Diseasevenous insufficiencyRadiologymedicine.symptomAzygos veinJugular VeinsCardiology and Cardiovascular Medicinebusiness030217 neurology & neurosurgeryAngioplasty BalloonMagnetic Resonance Angiographydescription
Abstract Purpose To evaluate relationship between Meniere disease (MD) and chronic cerebrospinal venous insufficiency (CCSVI) using ultrasound, magnetic resonance (MR) imaging, and venography and to evaluate the effectiveness of angioplasty of the internal jugular vein (IJV) and azygos vein (AV) in reducing symptoms of MD. Materials and Methods Patients with a confirmed diagnosis of MD unresponsive to standard treatment underwent duplex ultrasound and MR imaging to diagnose CCSVI. Healthy volunteers were also studied to evaluate CCSVI in asymptomatic subjects. Patients with CCSVI and MD underwent venography and percutaneous transluminal angioplasty (PTA) of IJV and AV. Results There were 182 patients with no clinical benefit from standard treatments evaluated. CCSVI was diagnosed in 175 (87.5%) patients with MD. Venography was performed in 69 patients to confirm the diagnosis of CCSVI. In 80% of these patients, PTA of the IJV and/or AV was effective for treating signs and symptoms of MD. In the healthy cohort, CCSVI was observed in only 12% of subjects. Conclusions These results suggest a possible etiologic relationship between CCSVI and MD that warrants further investigation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-05-12 |