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RESEARCH PRODUCT

Soluble ST2 and Diuretic Efficiency in Acute Heart Failure and Concomitant Renal Dysfunction

Sergio García-blasGema MiñanaPau LlàcerElena Revuelta-lópezAnna MollarAlberto CorderoImprove-hf InvestigatorsLorenzo FácilaRuth SánchezAgustín Fernández-cisnalRafael De La EspriellaClara BonanadSilvia VenturaEnrique SantasJulio NúñezJuan SanchisAntoni Bayes-genisVicent Bodí

subject

Heart Failuremedicine.medical_specialtybusiness.industrymedicine.medical_treatment030204 cardiovascular system & hematologymedicine.disease03 medical and health sciences0302 clinical medicineFurosemideNegatively associatedInternal medicineConcomitantHeart failureAcute DiseasePost-hoc analysisCardiologyHumansMedicineKidney DiseasesIn patient030212 general & internal medicineDiureticDiureticsCardiology and Cardiovascular Medicinebusiness

description

Abstract Background Identifying patients at risk of poor diuretic response in acute heart failure (AHF) is critical to make prompt adjustments in therapy. The objective of this study was to investigate whether the circulating levels of soluble ST2 predict the cumulative diuretic efficiency (DE) at 24 and 72 hours in patients with AHF and concomitant renal dysfunction. Methods and Results This is a post hoc analysis of the IMPROVE-HF trial, in which we enrolled 160 patients with AHF and renal dysfunction (estimated glomerular filtrate rate of Conclusions In patients with AHF and renal dysfunction at presentation, circulating levels of sST2 were independently and negatively associated with a poor diuretic response, both at 24 and 72 hours.

yearjournalcountryeditionlanguage
2021-04-01Journal of Cardiac Failure
https://doi.org/10.1016/j.cardfail.2020.10.002